I've got an issue using VS to do a deploy to a Fez Mini micro.  Here's what happens.

In debug the app works fine.  I can talk to any of the com ports on the micro just fine.  Both transmit and receive.

After a successful deploy of a release version, I reboot the micro by toggling the power.  The burned in app responds just as it should by announcing on the com port that the system has booted up.  I try to send a command from my PC to the micro and it seems to never get the interrupt.  The strange thing is that it works fine in debug mode.  I've checked my grounds and all are fine.  I've changed com ports on the micro, same issue, works fine in debug mode but fails in standalone mode.

Any ideas? 

BTW, I'm using a three wire interface to talk to the micro.  Tx, Rx and ground.  Should I have to turn off handshaking?  If so how?